Biomaterials for Protein Delivery and Tissue Engineering
Harnessing natural affinity interactions for precise protein delivery
Welcome to the Hettiaratchi Lab
We are a bioengineering research group at the University of Oregon’s Knight Campus for Accelerating Scientific Impact.
We welcome new lab members from all backgrounds and recruit through a variety of science and engineering graduate and undergraduate programs at the University of Oregon.
Our Approach
We combine expertise in chemical and biomedical engineering to design biomaterials to control protein delivery to injured tissues.
Directed Evolution for Protein Delivery
Cell-Instructive Biomaterials for Bone Repair
Predictive Bio-transport Modeling
Funding Sources
We are grateful for funding from the Collins Medical Trust, OHSU Medical Research Foundation, Department of Defense, National Institutes of Health, National Science Foundation, and Wu Tsai Human Performance Alliance.
Featured Publications
- Svendsen, J.E., Ford, M.R., Asnes, C.L., Oh, S.C., Dorogin, J., Fear, K.M., O'Hara-Smith, J.R., Harms, M.J., Hosseinzadeh, P., Hettiaratchi, M.H. (2024). Applying computational protein design to engineer affibodies for affinity-controlled delivery of vascular endothelial growth factor and platelet-derived growth factor. bioRxiv.
- Mozipo, E.A., Galindo, A.N., Khachatourian, J.D., Harris, C.G., Dorogin, J., Spaulding, V.R., Ford, M.R, Singhal, M., Fogg, K.C., Hettiaratchi, M.H. (2024). Statistical optimization of hydrazone-crosslinked hyaluronic acid hydrogels for protein delivery. Journal of Materials Chemistry B.
- Galindo, A.N., Frey Rubio, D.A., Hettiaratchi, M.H. (2024). Biomaterial strategies for regulating the neuroinflammatory response. Materials Advances.
- Fosnacht, K.G., Dorogin, J., Jefferis, P.M., Hettiaratchi, M.H., Pluth, M.D. (2024). An expanded palette of fluorescent COS/H2S-releasing donors for H2S delivery, detection, and in vivo application. Angewandte Chemie International Edition.
- Dorogin, J., Hochstatter, H.B., Shepherd, S.O., Svendsen, J.E., Benz, M.A., Powers, A.C., Fear, K.M, Townsend, J.M., Prell, J.S., Hosseinzadeh, P., Hettiaratchi, M.H (2023). Moderate-affinity affibodies modulate the delivery and bioactivity of bone morphogenetic protein-2. Advanced Healthcare Materials.
- Dorogin, J., Townsend, J.M., Hettiaratchi, M.H. (2021). Biomaterials for protein delivery for complex tissue healing responses. Biomaterials Science.
LinkedIn / Twitter
June 2024
Congratulations to Morrhyssey Benz for being awarded the 2024 Biochemistry Achievement Award from the Chemistry Department!
Alycia Galindo is awarded the Best PhD Student Presentation for the Knight Campus Bioengineering Seminar Series!
Congratulations to Alyssa Chi for being awarded the Wu Tsai Human Performance Alliance Undergraduate Research Fellowship!
May 2024
Congratulations to Jenna Khachatourian on winning an award for her oral presentation at the 2024 Wu Tsai Human Performance Alliance Spring Symposium!
Jonathan Dorogin is deemed a Cameron Innovation Fellow after winning an award through the Oregon Innovation Challenge!
Congratulations to Payton Jefferis for being awarded the VPRI Fellowship for summer research!
Congratulations to Caroline Foskett for being awarded the University of Oregon SPUR summer fellowship!
Congratulations to Armaan Hajar for accepting an internship at Intel!
April 2024
David Frey is awarded the prestigious Graduate Research Fellowship from the National Science Foundation! Congratulations, David!
Justin Svendsen is featured in the Oregon Quarterly for his collaborative work and with the College of Business through an Oregon Innovation Challenge award!
Jonathan Dorogin is named to the 2024 CAS Future Leaders Top 100 program list!
January 2024
Congratulations to our 2024 Knight Campus Undergraduate Scholars: Madeleine Ford and Alayna Huque!
December 2023
Congratulations to Justin Svendsen for winning the Knight Campus Research Collaboration Award!
May 2023
Congratulations to Madeleine Ford for winning the VPRI Undergraduate Research fellowship!
Juan Garcia is awarded the Wu Tsai Human Performance Alliance Undergraduate Research Fellowship!
January 2023
The lab also receives an Extramural Research Grant from MTF Biologics! Read more about the award here!
Congratulations to our 2023 Knight Campus Undergraduate Scholars: Morrhyssey Benz, Payton Jefferis, and Jenna Khachatourian!
December 2022
Marian is awarded a prestigious CAREER Award by the National Science Foundation. Check out more in the article featured on the Knight Campus website!
November 2022
Congratulations to Jonathan Dorogin for being awarded the prestigious NSERC PGS-D fellowship!
July 2022
Jonathan Dorogin wins a TERMIS Travel Award for the 2022 TERMIS-AM conference in Toronto!
June 2022
Congratulations to both Morrhyssey Benz and Madeleine Ford for each receiving a University of Oregon SPUR summer fellowship!