Hettiaratchi Lab

Biomaterials for Protein Delivery and Tissue Engineering

Harnessing natural affinity interactions for precise protein delivery

Welcome to the Hettiaratchi Lab

We are a bioengineering research group at the University of Oregon’s Knight Campus for Accelerating Scientific Impact.

We welcome new lab members from all backgrounds and recruit through a variety of science and engineering graduate and undergraduate programs at the University of Oregon.

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Our Approach

We combine expertise in chemical and biomedical engineering to design biomaterials to control protein delivery to injured tissues.

Directed Evolution for Protein Delivery

Cell-Instructive Biomaterials for Bone Repair

Predictive Bio-transport Modeling

Funding Sources

We are grateful for funding from the Collins Medical Trust, OHSU Medical Research Foundation, National Institutes of Health, and Wu Tsai Human Performance Alliance.

Featured Publications

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December 2021

Our research neighborhood is featured on the Knight Campus website for recent NIH grants awarded to our lab, the Plesa lab, and the Hosseinzadeh lab.

Congratulations to Henry Hochstatter for winning an Undergraduate Research Opportunity Program Mini-grant and to Yan Carlos Pacheco for winning the Knight Campus Diversity Award!

November 2021

Several lab members won awards for their presentations at the Oregon Bioengineering Symposium! Congratulations to John O’Hara-Smith (1st place, flash talk), Ireland John (2nd place, flash talk), and Henry Hochstatter (1st place, undergraduate poster)!

October 2021

The lab receives an R21 Trailblazer Award from the National Institute of Biomedical Imaging and Bioengineering! This $602,000, 3-year award will fund the lab’s work in using directed evolution to identify novel binding partners for affinity-controlled protein release. 

September 2021

Dr. Hettiaratchi wins a Faculty Research Mentor Award from the Center for Undergraduate Research & Engagement. Thanks to our undergrad researchers for the nomination!

July 2021

The Knight Campus receives a second $500 million gift from Phil and Penny Knight! See more details and the video of the official announcement here. 

June 2021

Congratulations to Henry Hochstatter for winning a UO SPUR summer fellowship!

Ireland Johnson is featured on the Knight Campus website as a Maybelle Clark Macdonald Scholar!

March 2021

The Hettiaratchi lab receives a Medical Research Foundation New Investigator Award to develop angiogenic biomaterials!

January 2021

We published our first review paper, led by graduate student Jonathan Dorogin, in the 2021 Emerging Investigators issue of Biomaterials Science.